Targeted optimal treatment regime learning using summary statistics
نویسندگان
چکیده
Summary Personalized decision-making, aiming to derive optimal treatment regimes based on individual characteristics, has recently attracted increasing attention in many fields, such as medicine, social services and economics. Current literature mainly focuses estimating from a single source population. In real-world applications, the distribution of target population can be different that Therefore, learned by existing methods may not generalize well popu- lation. Because privacy concerns other practical issues, individual-level data are often available, which makes regime learning more challenging. We consider problem estimation when populations heterogeneous, available only summary information covariates, moments, is accessible develop weighting framework tailors for given leveraging statistics. Specifically, we propose calibrated augmented inverse probability weighted estimator value function estimate an maximizing this within class prespecified regimes. show proposed consistent asymptotically normal even with flexible semi/nonparametric models nuisance approximation, variance consistently estimated. demonstrate empirical performance method using simulation studies real application two datasets sepsis.
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ژورنال
عنوان ژورنال: Biometrika
سال: 2023
ISSN: ['0006-3444', '1464-3510']
DOI: https://doi.org/10.1093/biomet/asad020